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Joaquim Cardoso MSc
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December 12, 2023
Columbia University
December 12, 2023
This prototype of an expanding artificial heart valve could make a big dent in the number of surgeries that many kids born with congenital heart disease need.
The problem: Many children receive prosthetic valves that help save their lives, but the valves cannot grow with the child.
“We need to replace the valve once, twice, up to four times to replace a valve that’s too small, but each of these open-heart surgeries comes with significant risks,” says David Kalfa, MD, PhD, associate professor of surgery at Columbia University Vagelos College of Physicians and Surgeons, director of the Pediatric Heart Valve Center, and surgical director of the Columbia Initiative for Pediatric Cardiac Innovation, whose lab created the prototype in collaboration with Jeffrey Kysar, PhD, professor of mechanical engineering.
An artificial heart valve that grows with the child could eliminate these risks.
The latest prototype from the team is built from a biocompatible polyurethane that closely matches the stretchiness of natural heart valves. To increase the size of the valve, a balloon catheter is inflated within the valve. “Because the polymeric material can deform permanently, the valve stretches and then remains at that new larger size to accommodate the growing child-until it needs to be stretched again,” Kysar says.
Testing of the valve demonstrated the feasibility of the concept, and the team is now building prototypes with improved materials and preparing to test their designs in animal models.
Photo courtesy of Abby Herschman, a PhD candidate in the Kysar lab who researches the material properties of the polymer used in the prototypes.
Originally published at https://www.cuimc.columbia.edu on December 12, 2023.
More information
“In Vitro Proof of Concept of a First-Generation Growth-Accommodating Heart Valved Conduit for Pediatric Use(link is external and opens in a new window)” was published in July 2023 in Macromolecular Bioscience.
Other collaborators on the project include Haim Waisman, PhD, professor and chair of civil engineering, and Vijay Vedula, PhD, assistant professor of mechanical engineering.
